Clodronic acid
Clodronic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-gated purine nucleotide uniporter SLC17A9.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 2 | — | 2 | 4 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | 1 | — | 1 | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | 1 | 2 |
| Osteoradionecrosis | D010025 | EFO_1001821 | — | — | — | 1 | — | 1 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | — | — | 1 | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | — | — | 1 | — | — | 1 |
| Brachial plexus neuropathies | D020516 | EFO_1000844 | G54.0 | — | — | 1 | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | — | — | 1 | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | — | — | — | 1 | 1 |
| Osteolysis | D010014 | — | M89.5 | — | — | — | — | 1 | 1 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | — | — | — | 1 | 1 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
| Femoral fractures | D005264 | — | S72 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Endodontics | D004708 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clodronic acid |
| INN | clodronic acid |
| Description | Clodronic acid is an organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. It has a role as a bone density conservation agent and an antineoplastic agent. It is an organochlorine compound, a one-carbon compound and a 1,1-bis(phosphonic acid). It is a conjugate acid of a clondronate(2-). |
| Classification | Small molecule |
| Drug class | calcium metabolism regulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=P(O)(O)C(Cl)(Cl)P(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 10596-23-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL12318 |
| ChEBI ID | 110423 |
| PubChem CID | 25419 |
| DrugBank | DB00720 |
| UNII ID | 0813BZ6866 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
SLC17A9
SLC17A9
Organism
Homo sapiens
Gene name
SLC17A9
Gene synonyms
C20orf59
NCBI Gene ID
Protein name
voltage-gated purine nucleotide uniporter SLC17A9
Protein synonyms
solute carrier family 17 (vesicular nucleotide transporter), member 9, Solute carrier family 17 member 9, Vesicular nucleotide transporter, vesicular nucleotide transporter SLC17A9, VNUT
Uniprot ID
Mouse ortholog
Slc17a9 (228993)
voltage-gated purine nucleotide uniporter SLC17A9 (Q8VCL5)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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328 adverse events reported
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